P2X2 receptor subunit immunoreactive respiratory neurones of the ventral respiratory group in the rat
نویسندگان
چکیده
The ventrolateral medulla (VLM) functions as a primary central chemoreceptive area, responsible for sensitivity to increases in arterial levels of PCO2 and mediating the ventilatory response to hypercapnia (Loeschcke, 1982). ATP acting via P2X receptors may be involved in mediating changes in the activity of medullary respiratory neurones during hypercapnia, thus playing an important role in central chemoreception (Spyer & Thomas, 2000). The objective of the present study was to determine whether respiratory neurones in the VLM contain P2X2 and/or P2X1 receptor subunits.
منابع مشابه
Neurochemistry and anatomy of the ventral medulla
The relationship between the anatomy and neurochemistry of neurons in the ventral medulla oblongata in regions that is responsible for cardiovascular, airways, and respiratory regulation was investigated. Microinjections of excitant amino acid (glutamate, 100 nl, 100 mM) were made throughout the ventral medulla in anesthetized rats. Arterial blood pressure, sympathetic nerve activity and phreni...
متن کاملNeurochemistry and anatomy of the ventral medulla
The relationship between the anatomy and neurochemistry of neurons in the ventral medulla oblongata in regions that is responsible for cardiovascular, airways, and respiratory regulation was investigated. Microinjections of excitant amino acid (glutamate, 100 nl, 100 mM) were made throughout the ventral medulla in anesthetized rats. Arterial blood pressure, sympathetic nerve activity and phreni...
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